FR194738 free base
CAS No. 204067-45-8
FR194738 free base ( —— )
Catalog No. M26220 CAS No. 204067-45-8
FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 447 | Get Quote |
|
10MG | 651 | Get Quote |
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25MG | 1017 | Get Quote |
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50MG | 1368 | Get Quote |
|
100MG | 1782 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameFR194738 free base
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NoteResearch use only, not for human use.
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Brief DescriptionFR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
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DescriptionFR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. FR194738 free base is a squalene epoxidase inhibitor.(In Vitro):FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM).?FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene.(In Vivo):FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride.?In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAntibacterial
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number204067-45-8
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Formula Weight439.7
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Molecular FormulaC27H37NO2S
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Purity>98% (HPLC)
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Solubility——
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SMILESCCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang X, Wang D, Zhou Z, Zhu W. Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods. Chemosphere. 2018 Jan;191:373-380.
molnova catalog
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