FR194738 free base

CAS No. 204067-45-8

FR194738 free base ( —— )

Catalog No. M26220 CAS No. 204067-45-8

FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 447 Get Quote
10MG 651 Get Quote
25MG 1017 Get Quote
50MG 1368 Get Quote
100MG 1782 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    FR194738 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
  • Description
    FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. FR194738 free base is a squalene epoxidase inhibitor.(In Vitro):FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM).?FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene.(In Vivo):FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride.?In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    204067-45-8
  • Formula Weight
    439.7
  • Molecular Formula
    C27H37NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang X, Wang D, Zhou Z, Zhu W. Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods. Chemosphere. 2018 Jan;191:373-380.
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